Jeffrey (Weber), a young gay man in New York, decides that sex is too much and decides to become celibate. He immediately meets the man of his dreams and must decide whether or not love is worth the danger of a boyfriend dying.

Grace Tang is an ambitious Wall Street banker determined to work her way up the ladder of life and out of working class Chinatown. When she attends a high-society party in New York City, everyone mistakes her for a famous Hong Kong heiress.

The times may have changed, but thankfully not the traits that make ex-roomies Felix Ungar (Lemmon) and Oscar Madison (Matthau) the all-time perfect mismatch.

Cybill is dismayed to learn that the soap opera character she portrays has been written into a coma along with Andrea, another veteran vixen, and that only one of them will recover.

Morgan Fairchild returns as one of Cybill's casting competitors who nabs another job from her and then announces that she's getting married to Maryann's ex-husband Dr. Dick. Taking matters into their own hands, the two conspire to sabotage the wedding reception.

Cybill’s agent Arthur dies and Cybill ends up planning his funeral, inviting look-alikes to attend. Maryann makes a move on Ira, but he rejects her.

Ira brings his new girlfriend to Zoey's sweet sixteen birthday party and Cybill and Maryann both like her until they discover she has uncontrollable multiple personalities. Meanwhile, Zoey and Sean, a busboy from the restaurant, are smitten with each other.

Cybill is pre-menopausal and experiencing hot and cold flashes. Not wanting to take hormones to relieve her symptoms, she decides to take the herbal approach.

Cybill has a date with movie star Dennis Oliver only to be lost in his shadow after the Oscars. He drops her off and asks to use her bathroom: she thinks he's trying to pull a fast one and is surprised when he excuses himself without even asking her for a night cap. He's arrested later that night for soliciting a prostitute and Cybill is tormented by the tabloids.

Children's show host Major Milo proposes to Cybill on the air, but she's much more interested in a hunky cable technician. Meanwhile, Ira and Maryann have a steamy dinner date that ends in disaster.