After attending the funeral of her grandmother in Dallas, Lisa Reisert boards the dreaded red eye for a flight back to Miami so she can make it to work the next day. On board, Lisa meets Jackson Ripner and their attraction grows. But moments after take-off, Jackson reveals that he has Lisa's father's wallet that he swiped off his desk and his real reason for being on board. Jackson needs Lisa's help to kill the deputy secretary of Homeland Security...

John McClane, the heroic New York cop with a knack for being in the wrong place at the right time, is back, and his latest predicament takes him all the way to Russia to track down his estranged son, Jack, who has been imprisoned in Moscow. But the mission takes a deadly turn as father and son must join forces to thwart a nuclear weapons heist that could trigger World War III.