Hoping to save their family and the citizens of Ferryport Landing from the evil plans of Mirror, Sabrina and Daphne Grimm seek counsel from the other magic mirrors, who advise them to join forces with the Scarlet Hand.

Led by Duncan "Gluestick" Dewey, the NERDS team uses brain power and courage rather than gadgets when they face off against supervillian Simon, his band of savage squirrels, and Albert, a middle-aged computer genius who lives with his mother.

When a virus infects Arlington, Virginia, home of NERDS headquarters, transforming victims into criminal masterminds, it is up to Flinch to stop its spread by miniaturizing himself and entering the head of the Villain Virus's creator, Heathcliff Hodges.

"There's a supervillain on the loose with a deep connection to the NERDS--and she's obsessed with destroying them. Miss Information recruits her own team members and gives them supernanobytes. She calls them the Brotherhood of Unstoppable Liars, Lowlifes, and Intimidating Enemies of Society (a.k.a. the BULLIES). They have a time machine. Although Ruby "Pufferfish" Peet has terrible allergies, she's a born leader. But her abilities as a field operative...

While running a spy network from their elementary school, five unpopular misfits combine their enhanced abilities and use cutting-edge gadgetry to fight evil around the world.

Fairy-tale detectives Sabrina and Daphne Grimm face their first case without Granny Relda's help when the future gets mixed up with the past in Ferryport Landing, and because some of the future does not look bright, Puck helps them try to make some changes.