Gru delights in all things wicked. Surrounded by an army of tireless little yellow minions, and armed with his arsenal of shrink rays, freeze rays, and battle-ready vehicles for land and air, he vanquishes all who stand in his way. Until the day he encounters the immense will of three little orphaned girls who look at him and see something that no one else has ever seen, a potential dad.

One day, Horton the elephant hears a cry for help coming from a speck of dust. Even though he can't see anyone on the speck, he decides to help it. Good thing since as it turns out, the speck of dust is home to the Whos, who live in their city of Whoville. Horton agrees to help protect the Whos and their home. Unfortunately for Horton, this gives him nothing but torment from his neighbors. They refuse to believe that anything could survive on the...