While fleeing from the cops, small time hood Harry Lockhart stumbles into an acting audition and does so well he gets sent to Hollywood. While there, Harry pursues a girl he loved in high school and gets caught up in a twisted murder mystery. His only chance of getting out alive is a gay private detective named Gay Perry, who also works as a consultant for movies and has been hired to tutor Harry in portraying a private eye.

Sherlock Holmes has always been the smartest man in the room, until now. There is a new criminal mastermind at large, Professor James Moriarty, and not only is he Holmes's intellectual equal, but his capacity for evil, coupled with a complete lack of conscience, may give him an advantage over the renowned detective. Holmes's investigation into Moriarty's plot becomes more dangerous as it leads him and Watson out of London to France, Germany, and finally...