A group of vampires resurrect "Drake" the all-powerful Count Dracula. Teaming up with the Nightstalkers, a group of similar-minded hunters, Blade is ready for battle. A scientist creates a potion that can kill Drake and the entire bloodsucking race.
The legendary "daywalker" Blade must join forces with a high-powered team of vampires to take on a fearsom threat more deadly than either has seen before. These unlikely allies must stop a race of super-vampires intent on destroying everyone in their path - human or vampire.