As Valentine's Day approaches, the students in Room 2B are preoccupied with kickball and a possible wedding between Horrible Harry and Song Lee.

Follows the school activities of second-graders, Harry and Doug, as they participate in a secret mission to celebrate "Charlotte's Web," learn how to make green slime, and put on a skit warning about the dangers of smoking.

When Song Lee's hampster escapes from its cage in Room 2B, the class members and other students in South School become involved in the search for him.

When Herbie Jones gets the dreaded girl disease and becomes lovesick for Annabelle Hodgekiss, it threatens to break up his friendship with his good pal Raymond.

After Herbie and Ray foil a robbery attempt at the local bank, they try to find a good home for the robber's dog.