When Federal Marshall Raylan Givens squares off against a known offender, he will warn the man, "If I have to pull my gun I'll shoot to kill." Except this time he finds the offender naked in a bathtub, doped up and missing his kidneys. Raylan knows there's big money in body parts, but by the time he finds out who is making the cuts, he is lying naked in a bathtub himself, Layla, the cool transplant nurse, about to go for his kidneys. It turns out...

Cable returns to his Arizona home to resume a quiet life. Instead, he finds Union sympathizers (David and Keith Carradine) have taken possession of the small spread. The war should be over. But Cable faces one more battle before the healing can begin.

A stewardess, a gun runner, a bail bondsman, a shifty ex-con, a stoned-out surfer girl, and an earnest federal agent converge in a quest for a missing half million dollars.