A global thriller about a wave of violent animal attacks against humans sweeping the planet. Jackson Oz, a young, renegade American zoologist who spends his days running safaris in the wilds of Africa, notices the strange behavior of the animals. As the assaults become more cunning, coordinated and ferocious, he is thrust into the race to unlock the mystery of the pandemic before there's no place left for people to hide.

The team's ongoing mission to keep America safe kicks off with a worldwide search for their own Director Vance. Escalating threats turn into personal missions as Bishop defies orders to reopen a cold case, a naval hospital endures an active shooter lockdown, and Gibbs is confronted by an ex-agent who issues a grave warning. At the end of the day, only one thing is certain: the team that fights together survives together.