In 1937, during the Depression, fifteen-year-old Mary Alice, initially apprehensive about leaving Chicago to spend a year with her fearsome, larger-than-life grandmother in rural Illinois, gradually begins to better understand and admire her grandmother's unusual qualities.

During the early days of the Civil War, the Pruitt family takes in two mysterious young ladies who have fled New Orleans to come north to Illinois.

A very small mouse of unknown origins runs away from school in the Royal Mews of Buckingham Palace shortly before the celebration of Queen Victoria's diamond jubilee, celebrating her sixty years on the British throne. The smallest mouse in London's Royal Mews is such a little mystery that he hasn't even a name. And who were his parents? His Aunt Marigold, Head Needlemouse, sews him a uniform and sends him off to be educated at the Royal Mews Mouse...

Blossom, high-school freshman and possessor of "second sight," helps an Egyptian princess, dead for 3500 years, to regain her tomb, and in addition saves a suffragette school teacher from losing her job in 1914.

In 1887, the social-climbing Cranstons voyage from New York to London, where they hope to find a husband for their awkward older daughter, secretly accompanied by Helena and her mouse siblings, for whom the journey is both terrifying and wondrous as they meet an array of titled humans despite their best efforts at remaining hidden.