It opens in 1926 as Newt Scamander has just completed a global excursion to find and document an extraordinary array of magical creatures. Arriving in New York for a brief stopover, he might have come and gone without incident, were it not for a No-Maj (American for Muggle) named Jacob, a misplaced magical case, and the escape of some of Newt's fantastic beasts, which could spell trouble for both the wizarding and No-Maj worlds.

In this retelling of the classic Western, a ranch enforcer raised by a powerful and ruthless cattle baron begins to doubt his own convictions and his foster father's motives after a string of deadly cattle rustlings.