A religion-based autocracy has taken over most of the United States, renaming the country Gilead. In this country women are second-class citizens. Anyone trying to escape is punished. One such person is June, who is captured while trying to escape with her husband and child and is sentenced to be a handmaid, bearing children for childless government officials. As a handmaid, June is renamed Offred.

"This season begins with a power vacuum that protagonists across Westeros and Essos look to fill. At Castle Black, Jon Snow struggles to balance the demands of the Night's Watch with those of the newly-arrived Stannis Baratheon, who styles himself as the rightful king of Westeros. Meanwhile, Cersei scrambles to hold on to power in King's Landing amidst the Tyrells and the rise of a religious group led by the enigmatic High Sparrow, while Jamie embarks...

After the shocking developments at the end of season 5 -- including Jon Snow's bloody fate at the hands of Castle Black mutineers, Daenerys' near-demise at the fighting pits of Meereen, and Cersei's public humiliation in the streets of King's Landing -- survivors from all parts of Westeros and Essos regroup to press forward, inexorably, towards their uncertain individual fates. Familiar faces will forge new alliances to bolster their strategic chances...