Contains four episodes that follow Ms. Frizzle and her class on their science adventures aboard the magic school bus where they go inside the human body.

When the Magic School Bus takes a dive, Wanda discovers that one of Ms. Frizzle's ancestors was Redbeard the Pirate and a treasure map leads the class to a coral reef where they learn first hand that life there is risky. In The Magic School Bus gets swamped, the class learns that swampland is an important haitat and natural water filter. In the Magic School Bus goes to Mussel Beach, the class learns about life along a shore.

Hundreds of years after our civilization was destroyed, a new world has emerged. A mysterious young woman named Hester Shaw leads a band of outcasts in the fight to stop London, now a giant predator city on wheels, from devouring everything in its path.