John and Jen are journalists who are a newly married couple. Marley is the adopted puppy that no one wants, a high-strung lab who is virtually untrainable. Marley shreds cushions, destroys floors and walls and most everything in between. Instead of taking him to the pound, they love their dog and he faithfully loves them in return. John and Jen eventually have three children and Jen gives up her career to be a mom. John's career continues to advance...

After Peter gets engaged to the woman of his dreams, he realizes he has not one friend to serve as his best man. To rectify the situation, he goes on a series of man-dates before he meets Sydney Fife, with whom he instantly bonds. While Peter and Sydney become closer, his relationship with his fiancee begins to suffer, forcing him to choose between her or his new B.F.F.