The hapless Roger Rabbit is framed for the murder of Marvin Acme, who was photographed "playing patticake" with Roger's wife Jessica. The mixed live and animated action takes place in Hollywood and next-door "Toontown," where humans and "Toons" co-exist.

Ten strangers are brought together at a motel because of a savage rainstorm. All take shelter at a desolate motel run by a nervous night manager. Relief in finding shelter is quickly replaced with fear as the ten travelers begin to die, one by one. They soon realize that, if they are to survive, they'll have to uncover the secret that has brought them all together.