Enola Holmes, much younger sister of detective Sherlock Holmes, must travel to London in disguise to unravel the disappearance of her missing mother.

Pursued by her much older brother, famed detective Sherlock Holmes, fourteen-year-old Enola, disguised and using false names, attempts to solve the kidnapping of a baronet's sixteen-year-old daughter in nineteenth-century London.

In late nineteenth-century London, fourteen-year-old Enola Holmes, much younger sister of detective Sherlock Holmes, turns to Florence Nightingale for help when her investigation into the disappearance of a Crimean War widow grows cold.

At age thirteen Dusie makes the horrifying discovery that she, like her New York artist mother, is a Gorgon--a Greek mythological monster sprouting snakes from her head and capable of turning humans into stone with one angry look.