Larry Daley is a divorced father who can't seem to keep a job for more than a week. As a last resort, Larry applies for a job as a night shift security guard at the American Museum of Natural History. However, a seemingly easy job turns out to be an adventure when he finds that an ancient curse causes the "inhabitants" of the museum to come to life at night.

Peter LaFleur is a charismatic underachiever and the proprietor of a rundown gym called Average Joe's. The facility's ecclectic cleintele is decidedly less-than-your-average Joes. Peter's humble gym catches the eye of White Goodman, the egomaniacal owner of Globo Gym. White places a foreclosing attorney inside the Average Joe's establishment to finalize his takeover of the gym, but attorney Kate is won over by Peter's boyish charm and joins the Average...

Greg Focker has finally begun to earn the respect of his ex-CIA father-in-law, Jack Byrnes, but one important test still lies ahead: will Greg prove that he has what it takes to be the family's next 'Godfocker', or will the circle of trust be broken for good?