History is larger than life, and twice as funny, in this monumental comedy sequel. Larry Daley is a former night watchman at the Museum of Natural History, where the exhibits come to life after dark. Now Larry's nocturnal friends are being retired to the archives of the Smithsonian Institution, luring him back for a hilarious, all-out battle against museum misfits who plan to take over the Smithsonian, and the world.

Queens native Josh Kovacs has managed one of the most luxurious and well-secured residences in New York City for more than a decade. Under his watchful eye, nothing goes undetected. In the swankiest unit atop Josh's building, Wall Street titan Arthur Shaw is under house arrest after being caught stealing two billion from his investors. The hardest hit among those he defrauded? The tower staffers whose pensions he was entrusted to manage.

Larry Daley is a divorced father who can't seem to keep a job for more than a week. As a last resort, Larry applies for a job as a night shift security guard at the American Museum of Natural History. However, a seemingly easy job turns out to be an adventure when he finds that an ancient curse causes the "inhabitants" of the museum to come to life at night.

The castaways are back together--and still lost! Stranded in the middle of Africa, they soon learn that all is not as it seems.