History is larger than life, and twice as funny, in this monumental comedy sequel. Larry Daley is a former night watchman at the Museum of Natural History, where the exhibits come to life after dark. Now Larry's nocturnal friends are being retired to the archives of the Smithsonian Institution, luring him back for a hilarious, all-out battle against museum misfits who plan to take over the Smithsonian, and the world.

Get ready for the wildest and most adventure-filled night as Larry spans the globe, uniting favorite and new characters while embarking on an epic quest to save the magic before it is gone forever.

Follow Central Park Zoo animals, including, Alex the Lion, Marty the Zebra, Melman the Giraffe and Gloria the Hippo, along with the psychotic penguins, the monkeys, and the lemur leaders as they unexpectedly are now stranded in the middle of Africa. While Alex, Marty, Melman and Gloria are rather happy with their new environment, they quickly realize that it's not all that it seems. Meanwhile, the penguins attempt to repair the plane that they accidentally...

Over the years, Megamind, has tried to conquer Metro City in every imaginable way. Each attempt, a colossal failure thanks to the caped superhero known as 'Metro Man, ' until the day Megamind actually defeats him in the throes of one of his botched evil plans. Suddenly, the fate of Metro City is threatened when a new villain arrives and chaos runs rampant, leaving everyone to wonder if the world's biggest 'mind' can actually be the one to save the...