John and Jen are journalists who are a newly married couple. Marley is the adopted puppy that no one wants, a high-strung lab who is virtually untrainable. Marley shreds cushions, destroys floors and walls and most everything in between. Instead of taking him to the pound, they love their dog and he faithfully loves them in return. John and Jen eventually have three children and Jen gives up her career to be a mom. John's career continues to advance...

Hotshot rookie race car Lightning McQueen is living life in the fast lane until he hits a detour on his way to the most important race of his life. Stranded in Radiator Springs, a forgotten town on the old Route 66, he meets Sally, Mater, Doc Hudson and a variety of quirky characters who help him discover that there's more to life than trophies and fame.

Three grown prodigies, all with a unique genius of some kind, and their mother are staying at the family household. Their father, Royal, had left them long ago, but now returns to make things right with his family.