While running a spy network from their elementary school, five unpopular misfits combine their enhanced abilities and use cutting-edge gadgetry to fight evil around the world.

When a former member of NERDS turns into a villainous cheerleader, Matilda "Wheezer" Choi and the rest of the NERDS must infiltrate the cheerleader squad and save the world from a machine that wreaks havoc by entering other dimensions.

"There's a supervillain on the loose with a deep connection to the NERDS--and she's obsessed with destroying them. Miss Information recruits her own team members and gives them supernanobytes. She calls them the Brotherhood of Unstoppable Liars, Lowlifes, and Intimidating Enemies of Society (a.k.a. the BULLIES). They have a time machine. Although Ruby "Pufferfish" Peet has terrible allergies, she's a born leader. But her abilities as a field operative...