1799, Dejima in Nagasaki Harbor. Jacob de Zoet, a devout and resourceful young clerk, has a chance encounter with Orito Aibagawa, the disfigured daughter of a samurai doctor and midwife to the city's powerful magistrate. The borders between propriety, profit, and pleasure blur until Jacob finds his vision clouded, one rash promise made and then fatefully broken--the consequences of which will extend beyond Jacob's worst imaginings.