In Whoville, live the Whos, an almost mutated sort of munchkinlike people. All the Whos love Christmas, yet just outside of their beloved Whoville lives the Grinch. The Grinch is a nasty creature that hates Christmas, and plots to steal it away from the Whos which he equally abhors. Yet a small child, Cindy Lou Who, decides to try befriend the Grinch.

The story of the relationship between a prominent high school football coach in a small South Carolina town and the illiterate, mentally-challenged man nicknamed Radio whom he mentors. Although their friendship raises some eyebrows at first, Radio's growth under the coach's guidance ultimately inspires the local townsfolk.

"Ghost therapist" Dr. James Harvey and his daughter Kat arrive at drafty, old Whipstaff Manor. Its greedy owner, Carrigan Crittendon, has hired Dr. Harvey to exorcise the house's apparitions: a friendly but lonely young ghost named Casper, who's just looking for a friend, and his outrageous uncles Stretch, Stinkie and Fatso (The Ghostly Trio). If the plan works, she and Dibs, her partner-in-slime, can get their hands on the manor's fabled treasure....